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BiomarkerLIVE Overview

The role of biomarkers and molecular profiling in cancer diagnosis and treatment continues to expand. In oncology, a biomarker can indicate cancer type, how a cancer will progress if left untreated, what specific treatment may be most effective for a given cancer, and how well treatment is working over time. For five of the most common types of cancer (lung, prostate, colorectal, breast, and skin), there are more than 75 biomarkers used in clinical practice. The sheer number of treatment options across tumor types and the complexity of delivering care makes it difficult for cancer care providers to integrate new therapeutics, like biomarker testing, into their practices.

Barriers to using biomarker testing are common. Respondents to ACCC’s 2018 Trending Now in Cancer Care Survey indicate that insurance coverage, reimbursement, and insufficient protocols are among the issues working against the widespread implementation of biomarker testing in oncology practices.

To help cancer care providers surmount these and other barriers and enhance their knowledge of this rapidly evolving treatment area, ACCC launched the first phase of BiomarkerLIVE in April 2019. Since then, ACCC has worked with clinical experts and industry leaders to develop a common lexicon of biomarker terminology to promote better communication among cancer care teams; establish a resource library of materials relevant to cancer biomarkers and biomarker testing; and host a how-to webinar that explores how cancer programs can use these tools to implement effective biomarker testing protocols for their patients.

Building on the success of BiomarkerLIVE’s launch, Phase 2 will help cancer providers better understand what is needed to facilitate the integration of precision medicine into everyday practice. The objective of this phase is twofold:

  • Support the multidisciplinary cancer care team with the development of the infrastructure and expertise necessary to facilitate the integration of precision medicine into everyday practice.
  • Develop new tools and platforms to disseminate relevant educational resources to the multidisciplinary cancer care team.
For more information on this project, please contact the ACCC Provider Education department.

On-Demand Webinars

  • This webinar will review how the steps in the life cycle of a patient specimen can affect its molecular integrity and molecular analysis results. Our expert speaker will define the roles of stewardship across the specimen chain of custody, discuss common factors that compromise specimen fitness for molecular testing, and describe solutions to improve preanalytics and tissue stewardship.

  • Two thought leaders who have deep knowledge of—and experience in—biomarker testing in patients with hematologic malignancies will discuss best practices for biomarker testing in chronic lymphocytic leukemia (CLL) and multiple myeloma based on patient case discussions and the latest guidelines.

  • Take a deeper dive into the differences between germline and somatic mutations and what this means for patients with cancer and their families. Considerations for tumor types where somatic and germline testing comes into play for colorectal, ovarian, pancreatic, and prostate cancers will be discussed.

  • This webinar will help participants better understand the role of laboratory medicine professionals and pathologists in biomarker testing and incorporate a review of testing techniques and applications, lab-specific regulations, and the impact of those regulations on biomarker testing.

  • This on-demand panel discussion provides a review pf the current policies and regulations that drive costs related to biomarker testing.

  • This on-demand webinar will explore the differences between germline and somatic mutations (with case examples), review AMP/ASCO/CAP guidelines, give somatic testing examples, and share findings from a LUNGevity/FORCE patient survey.

  • Gain an introduction to cancer biomarkers and its relevant terminology, review different types of biomarkers, discuss the current landscape of biomarker-driven therapies by tumor type, and implications for cancer care delivery.

Presentations & Abstracts

Publications

accc-biomarker-provider-guide-77x100Talking with Your Patients About Biomarker Testing in Cancer Care - Provider Tips
This fact sheet supplies information to assist providers in talking with patients about biomarker testing and its role in their care.

accc-biomarker-patient-guide-77x100Conversation Guide: Biomarker Testing and its Role in Your Cancer Journey
A set of questions to guide patient-provider conversations related to biomarker testing. Type answers in this fillable PDF, or print blank copies for patients to write their own notes.

Biomarker Testing in Practice: Process Improvement Toolkit
Review the four key elements needed when developing a precision medicine program that successfully incorporates biomarker testing.

Application of Biomarkers in Clinical Trials
This white paper details considerations when determining to conduct biomarker testing on a patient, and the role the test results may play in potentially making that patient eligible for future clinical trials.

Cancer Buzz Podcasts

From the ACCCBuzz Blog

ACCC Commemorates World Lung Cancer Day—10 Years Strong


August 01, 2022

Communities around the globe recognize August 1 as World Lung Cancer Day—a day to commemorate, educate, and support individuals and families impacted by lung cancer. Today, in its 10th year, World Lung Cancer Day brings new hope to patients with the disease as rapid advancements in diagnostics, genomics, and precision medicine are transforming lung cancer diagnosis and treatment. Cancer programs and practices everywhere are working hard to implement and expand their use of biomarker testing, molecularly targeted therapies, and genetic counseling every day, which means new treatment options and improved outcomes for patients with lung cancer. More than ever before, greater emphasis is placed on reducing the cancer burden by avoiding risk factors, exercising evidence-based prevention strategies, and early detection. 

However, despite these incredible strides, World Health Organization estimates show that 2.21 million new lung cancer cases were diagnosed and 1.8 million people died from the disease in 2020 worldwide. In 2022, the American Cancer Society estimates that 236,740 Americans will be diagnosed with lung cancer and 130,180 Americans will lose their battle against the disease. Simply, these statistics mean that our work is not done.

As such, ACCC continues to focus its efforts on developing comprehensive resources for multidisciplinary cancer care teams and patient advocates to better support lung cancer treatment. These resources provide a front-row seat to the innovative science and research developments surrounding biomarkers, molecularly targeted therapies, and genomics that are currently underway; best practices and recommendations for improving clinical care and eliminating disparities related to access and treatment of lung cancer; disease-specific case studies; as well as a plethora of other resources like webinars, e-learning opportunities, patient-education materials, workshops, and quality-improvement publications. 

ACCC is sharing the latest and greatest in lung cancer diagnostics and therapies through real-world tools and information that care teams can access and implement into their cancer program or practice today. Below are a few highlights from ACCC’s expansive list of lung cancer initiatives:

Stage III/IV Non-Small Cell Lung Cancer

ACCC conducted a national, multi-phase effort to explore care coordination and communication within the multidisciplinary cancer care team. This effort uncovered barriers and developed process improvement plans for cancer programs to support care optimization for patients with Stage III/IV non-small cell lung cancer. 

Six cancer programs from a variety of settings and locations across the United States participated in a six-month ACCC quality improvement (QI) initiative, and the results of this project can be reviewed online. Additionally, participate in ACCC’s World Lung Cancer Day LinkedIn Live Event (August 1 at 1:00 PM EST) to learn about the project’s key findings and improvements your cancer program can make for this patient population. 

Biomarker Testing 

Barriers to using biomarker testing are common; factors, such as insurance coverage, reimbursement, and insufficient protocols, are among the many issues working against widespread implementation of biomarker testing in cancer programs and practices. To help oncology professionals surmount these barriers and enhance their knowledge of biomarkers, ACCC launched the first phase of its BiomarkerLIVE project in April 2019. Building on the project’s success, Phase II helped cancer professionals better understand what is needed to facilitate the integration of precision medicine into everyday oncology practice. 

Look for the Biomarker Testing in Practice: Process Improvement Toolkit that examines the four key elements needed to develop a successful precision medicine program, including biomarker testing, as well as the soon-to-be-released Biomarker Discussion Guide.

Early Stage IB/IIIA Non-Small Cell Lung Cancer

ACCC is conducting a nationwide initiative across various care settings to provide guidance to multidisciplinary cancer care teams on key issues related to providing optimal care for patients with early stage IB/IIIA non-small cell lung cancer. In part with this initiative, a national survey, released on July 12, 2022, is currently underway which will assess current practice patterns and challenges regarding care delivery and management of this patient population. Survey data will address the potential value of biomarker testing, identify gaps in coordination of care, and highlight effective practices to caring for patients with early stage IB/IIIA non-small cell lung cancer.

Precision Medicine in Lung Cancer

ACCC—and its partners at LUNGevity and the Center for Business Models in Healthcare—are working with three cancer program sites to develop patient and provider interventions to promote biomarker testing for those with lung cancer in underserved communities. Participating cancer program sites will pilot the 4R (right information/care/patient/time) care delivery model that enables patients and care teams to manage timing and sequence of interdependent, time sensitive care with a 4R Care Sequence plan—a one-page, personalized care project plan and roadmap used by the team to plan and deliver care. ACCC has also developed a list of patient-centered resources for those living with lung cancer and will be releasing a helpful guide with tips and talking points for providers to promote clear and consistent communication to patients about biomarker testing.

Read about key insights from this initiative in ACCC’s peer-reviewed journal Oncology Issues:

Then look for comprehensive research outcomes and helpful resources, including an online course on promoting organization health literacy on lung biomarker testing that is scheduled to be released in early 2023.

View a comprehensive list of all ACCC projects dedicated to lung cancer available on our website.

News & Media

 
 

Our Partners


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Our Supporters

logo-abbvie-200x80 AstraZeneca_200x80 This project is supported by AbbVie, AstraZeneca, Lilly Oncology, and Merck & Co., Inc. BMS-330x80 Phase one of this project was supported by Bristol Myers Squibb.