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Multidisciplinary Breast Cancer Resources

Addressing Challenges in Oral Therapies for HR+, HER2- Breast Cancer

HR+ HER2- breast cancer is the most common subtype of breast cancer, accounting for about 70 percent of breast cancer cases.1,2 An HR+, HER2- diagnosis can require a complex treatment regimen tailored to an individual patient, that may include hormone therapy, chemotherapy, or a combination of these.3

The complex and evolving treatment landscape for locally advanced or metastatic HR+, HER2-breast cancer poses a challenge to community oncologists, who are tasked with ensuring the tolerability and adherence of patients to their treatment regimens. Difficult dosing schedules and side effect profiles of oral anti-cancer therapies require working knowledge of a rapidly growing body of medical literature.

As oral anticancer medications become a common treatment option, patient adherence to medication is essential to ensuring positive clinical outcomes. ACCC developed the “Addressing Challenges in Oral Therapies for HR+, HER- Breast Cancer,” to identify challenges with oral anti-cancer therapies and provide methods to better support patients.

Resource Library

Vodcast Series

Financial Barriers to Oral Cancer Therapies

CBTV Episode 19Oct 19, 2022

Tune-in as our expert discusses how and when to screen patients, and then connect them to available resources to better support patients’ financial needs.

Patient Adherence to Oral Targeted Therapies

CBTV Ep 18Oct 6, 2022

In this episode, our experts examine challenges with oral anti-cancer therapies and provide methods to better support patients. 

Addressing Challenges in Managing Patients Receiving Oral Therapies for HR+, HER2- Breast Cancer

CBTV Ep 17Sep 29, 2022

Hear how to educate patients and their caregivers about the risks and benefits to oral therapies for breast cancer. 

Oral Cancer Therapy: Adverse Events

CBTV Ep 13 Thumbnail
Jul 28, 2022

With the  emergence of oral cancer therapies, it is a very exciting time in cancer care.  But these treatments can come with adverse events.


  1. Cancer Stat facts: female breast cancer subtypes. National Cancer Institute. Accessed May 4, 2022. 
  2. Breast cancer facts & figures 2019-2020. American Cancer Society. Accessed May 4, 2022. 
  3. NCCN Clinical Practice Guidelines in Oncology. Breast Cancer, version 2.2022. Accessed Mar 4, 2022. 

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Eliminating Disparities in Access to Quality Cancer Care in African American Women with Triple Negative Breast Cancer

African Americans are disproportionately affected by the prevalence and severity of breast cancer and consistently exhibit poorer health outcomes. For example, African American women have a higher risk of developing triple negative breast cancer (TNBC)—which represents approximately 15% to 20% of all breast cancer cases—than any other racial or ethnic group. A 2021 publication from the Tigerlily Foundation found that 53% cases of TNBC are diagnosed in African American women under age 50, compared to 16% of White women.

People with TNBC have worse prognoses than those with other breast cancer subtypes. They also have a shorter time to relapse after standard chemotherapy, a higher frequency of metastases to the lung, liver, and brain, and an overall lower survival rate. A 2020 study found non-biologic contributing factors to poorer outcomes for TNBC, such as poverty, social stress, unsafe neighborhoods, and lack of healthcare access. These factors have been demonstrated to negatively affect the stage of diagnosis and length of survival for patients with TNBC.

To effectively manage TNBC, the patient must receive regular care, follow strict adherence to treatment regimens, and identify and seek support of any side effects. Although patient self-empowerment is imperative for increasing medication adherence and side effect management, it remains difficult to address in underserved populations.

ACCC is partnering with the Tigerlily Foundation to capture patient and provider perspectives on the specific challenges and barriers they encounter regarding the diagnosis and treatment of TNBC. Experts on care disparities will collect and analyze these perspectives to guide the development of specific interventions to eliminate identified knowledge and practice gaps.

As part of this initiative, we will develop a patient-provider care sequence plan that will map the entire cancer care journey, from diagnosis through treatment to survivorship care. The utility and feasibility of these plans will be assessed by implementing them at two ACCC member cancer programs. These patient-centric interventions will target the entire multidisciplinary cancer care team, as well as patients and their caregivers.





This project was made possible by support from Gilead Sciences Inc. and AstraZeneca.


Making Sense of the Evolving Standards of Care for Advanced HER2+ Breast Cancer

Overexpression or amplification of the human epidermal growth factor receptor 2 (HER2) is present in approximately 15 percent to 20 percent of patients with metastatic breast cancer. First-line therapy with anti-HER2 targeted agents have significantly improved outcomes for patients with HER2-positive breast cancer. Nevertheless, most of these patients eventually relapse.

Novel therapies have recently become available for patients who continue to progress following first and second-line anti-HER2 targeted therapies. As the number of these therapies increases, so too does the challenge for providers to keep current on the latest clinical advances.

While anti-HER2 targeted agents have improved outcomes, they also require providers to closely monitor and manage potential treatment-related adverse events. Because many practitioners treat a wide range of tumor types; they often find it challenging to stay up to date with recent safety and efficacy data for targeted therapies. In previous ACCC educational programs, community oncology practitioners have said that keeping current with clinical advances is a primary barrier to implementing best practices in managing patients being treated by targeted therapies.

This project enabled a series of meaningful small-group interactions among clinicians involved in the care of breast cancer patients that —through a variety of collaborative educational experiences—helped them optimally manage patients with HER2-positive breast cancer who have received prior anti-HER2 targeted therapies.

Abstracts & Presentations

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Jointly Provided By

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AstraZenecaDaiichi Sankyo
This educational activity is supported by educational grants from AstraZeneca Pharmaceuticals and Daiichi Sankyo


Managing Patients with HER2+ Breast Cancer

ACCC is partnering with AXIS Medical Education in an educational research project to assess the value of a robust, independent, quality-focused educational intervention that aims to improve  quality measures related to management of patients with HER2+ breast cancer (all stages). The online educational interventions offered will include clinical updates, case application, and quality processes.

The project will run approximately 12-18 months. Two ACCC Member programs have been selected to participate in baseline data collection, a practice survey, a live focus group, a series of online educational interventions, and post-intervention data collection. The project team will work closely with the participating programs to ensure a smooth and successful experience.

Participating Cancer Programs:

The Lefcourt Family Cancer Treatment & Wellness Center at Englewood Hospital and Medical Center
Englewood, NJ
Research Coordinator: Christina Cancel

UNC REX Cancer Care
UNC REX Hospital
Raleigh, NC
Research Coordinator: Cynthia Jones, BSHA, CPHQ

Study Design

HER2 Breast Cancer Study Design Graphic

Joint Provider


Our Supporter


Funding & support provided by Genentech


Quality Improvement in Breast Cancer Through BRCA Testing

In a recent ACCC survey of community oncology practitioners, more than 80 percent of respondents reported that 50 percent or fewer of their patients with early or metastatic breast cancer have ever had germline BRCA mutation testing. The survey revealed both patient- and provider-related barriers to BRCA testing, including institutional barriers.

To support quality improvement (QI) projects in breast cancer, ACCC has partnered with Pfizer Global Medical Grants to award more than $1.8 million in funding to 15 projects that are aimed at improving the quality of breast cancer patient care. The projects will focus on conducting quality improvement  initiatives that support increasing the rates of BRCA testing for patients with early stage or metastatic breast cancer.

Access the Survey Summary Report

The grant awards are providing an opportunity for community oncology programs to implement initiatives that will address barriers to counseling and testing. The grantees will utilize innovative approaches to extend best practices to a much larger patient population, including underserved minority patient groups. As part of the initiatives, sites will review their progress and evaluate how changes in testing practices impact treatment decision-making.

The following organizations were selected to participate:

  • Anne Arundel Medical Center, Annapolis, MD
  • Cabell Huntington Hospital Foundation, Huntington, WV
  • Christiana Care Health System, Newark, DE
  • Franciscan Health Foundation, Mishawaka, IN
  • Kalispell Regional Medical Center, Kalispell, MT
  • Maine Medical Center, Portland, ME
  • Northside Hospital Cancer Institute, Atlanta, GA
  • Northwest Medical Specialties, Tacoma, WA
  • Oncology Hematology Care, Inc., Cincinnati, OH
  • Southeastern Regional Medical Center, Lumberton, NC
  • Saint Vincent Hospital, Indianapolis, IN
  • The Outer Banks Hospital, Nags Head, NC
  • University of Kansas Medical Center, Kansas City, KS
  • University of Maryland Upper Chesapeake Health, Bel Air, MD
  • White Memorial Medical Center Charitable Foundation, Los Angeles, CA

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For more information on any of these projects, please contact the ACCC Provider Education department.