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Precision Medicine Stewardship

Researchers have made great strides in identifying mutations that drive uncontrolled cellular growth and, ultimately, cancer. There remains a well-recognized disconnect, however, between guideline-concordant testing and real-word clinical practice. Medically underserved populations in particular face significant challenges to accessing the latest advances in cancer diagnostics.

For example, a 2019 National Cancer Institute study found that, in 2013 and 2014, of 83,000 women from large cancer registries in California and Georgia, only about 25% of those with breast cancer and 33% of those with ovarian cancer were tested for known harmful genetic variants. While large racial and socioeconomic disparities in testing rates were not observed among patients with breast cancer, among patients with ovarian cancer, testing rates were far lower for Black patients than White patients (22% vs. 34%) and for uninsured patients than insured patients (21% vs. 35%).

In response to these disparities, some oncology practices have developed innovations to remove barriers to widespread biomarker testing. One such solution is for cancer programs to designate a “precision medicine steward”—a navigation lead that serves as the point person for removing barriers to testing so all eligible patients are appropriately tested.

This program will highlight effective Precision Medicine Steward programs, evaluate challenges and explore best practices while defining the unique responsibilities of the steward role. This program will demonstrate the utility and feasibility of the steward role as an important member of the multidisciplinary panel within the oncology team.

For more information on this project, please contact the ACCC Provider Education department.

Featured Video

In this video, ACCC members share highlights from their journey to streamline precision medicine testing processes and improve the patient biomarker navigation experience through the addition of precision medicine stewards.

Featured Articles

An Innovative Approach to Navigating Patients Through Cancer Diagnostics

Navigating Patients Through Cancer Diagnostics-200x237ACCC’s Precision Medicine Stewardship education program brought together experts from oncology programs across the United States for a series of focus groups on the mechanics, advantages, and feasibility of this important role. Learn how these teams have successfully integrated stewardship roles into practice.

A Financial Advocate's Guide to Biomarker Testing in Cancer

A-Financial-Advocate-Guide-to-Biomarker-Testing-in-Cancer-200x252As more cancer patients undergo biomarker testing, financial advocates play a key role in ensuring that patients receive the highest quality of care without the added stress of economic hardship. Read ACCC's “A Financial Advocate's Guide to Biomarker Testing” to learn more.

Precision Medicine Stewardship: A Model from Astera Cancer Care

A-Model-from-Astera-Cancer-Care-200x252As part of its precision medicine stewardship education program, ACCC recently spoke with Astera Cancer Care in New Jersey about its innovative approach to meet the demands of increased precision medicine testing by creating a centralized molecular processing department. Access this document to learn more about how this model significantly streamlined processes and reduced the amount of time between testing and patient treatment.


On-Demand Webinar

  • This webinar will highlight how community cancer programs are using a new approach to optimize biomarker testing processes through the addition of a precision medicine steward. Precision medicine experts will outline strategies and key metrics that demonstrate how precision medicine stewardship can improve coordination and streamline workflows to ensure timely, equitable testing for patients who may benefit from targeted therapy.

From the ACCCBuzz Blog

  • Achieving Health Equity in Oncology with Precision Medicine Stewards
    April 20, 2023
    ACCCBuzz spoke with Luis E. Raez, MD, FACP, FCCP, to learn more about the importance of closing the gap in access to biomarker testing and strategies to improve equity and inclusion in precision medicine.
  • Precision Medicine Trends: Stewardship Is on the Rise
    March 16, 2023
    With the variety of models and titles that have emerged under precision medicine stewardship, learn how one cancer program is breaking down the this complex landscape into streamlined workflows to improve efficiency and better support growing test volumes.
  • Precision Medicine Stewards: The Next Step in Personalized Medicine
    December 15, 2022
    ACCC shares how a precision medicine steward—a dedicated navigator focused specifically on biopsy samples and biomarker testing processes and results—can make a daunting biomarker testing process incredibly efficient for cancer programs and practices everywhere.
  • Manipulating Data to Make Precision Medicine Magic
    November 22, 2022
    Dr. John Strickler from Duke Cancer Institute sat down with ACCCBuzz to talk about molecular profiling and data, including the cancer institute's own journey in oncology precision medicine.

From Oncology Issues


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This project is made possible by support from AstraZeneca and Blueprint Medicines.