In This Section

HCC Resources

HCC Treatment Guidelines and Guidance

AASLD Guidelines for the Treatment of Hepatocellular Carcinoma (HCC)
American Association for the Study of Liver Diseases (AASLD) official recommendations on the surveillance, diagnosis, and treatment of hepatocellular carcinoma (HCC) occurring in adults with cirrhosis. 

Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases
This guidance provides a data-supported approach to the diagnosis, staging, and treatment of patients diagnosed with HCC, put forward to help clinicians understand and implement the most recent evidence.  

AASLD Practice Guidelines  
Homepage for all AASLD practice guidelines, including HCC Management, Liver Biopsy, and Liver Transplantation.  

NCCN Clinical Practice Guidelines for Hepatobiliary Cancers 
[free but requires login] 
Includes guidelines for screening, diagnosis, and treatment for patients diagnosed with hepatobiliary cancers. 

HCC Screening Information and Guidance

AASLD Guidelines for the Treatment of HCC
Guidelines include a section on recommended populations to surveil and methods for surveillance. 

Surveillance for hepatocellular carcinoma in adults 
(UptoDate, open access) 
Reviews the approach to surveillance for hepatocellular carcinoma (HCC) in high-risk patients and follow-up testing for lesions found during surveillance. 

Surveillance for Hepatocellular Carcinoma  
From Hepatitis C Online, a free educational website from the University of Washington National Hepatitis Training Center. This course provides a summary of indications, methods, and guidance for surveillance in hepatitis patients.  

Liver (Hepatocellular) Cancer Screening (PDQ®) – Health Professional Version 
National Cancer Institute Physician Data Query.  

No association between screening for hepatocellular carcinoma and reduced cancer-related mortality in patients with cirrhosis 
Moon AM, Weiss NS, Beste LA, Su F, Ho SB, et al. Gastroenterol. 2018; 155(4):1128–1139. 

Should We Abandon Current Hepatocellular Carcinoma Screening Practices [editorial]? Cooper GS. Gastroenterol. 2018;155(4):972-974. 

Above includes an article by Moon and colleagues with findings from a study of HCC mortality within the Veterans Administration system and an editorial response addressing in adequacies of current screening strategies.  

HCC Continuing Education and Training Resources

Unresectable HCC and RCC: Treatment Related Adverse Event Management  
CME activity that covers adverse event management for unresectable hepatocellular carcinoma (HCC). Medscape CME/ABIM MOC/CE Released: 11/26/2019, valid for credit through: 11/26/2020 

Clinical Advances in Hepatocellular Carcinoma Management – Rapid Response from Chicago  
CME activity that covers clinical evidence regarding targeted and/or immunotherapy and toxicity management.  

Hepatocellular Carcinoma Webcast    
Webcast (free) with CME option (paid) from Wexner Medical Center at The Ohio State University. Includes overview of the epidemiology of HCC, identification of patients for screening, diagnosis, and treatment. 

LiverLearning from AASLD (Membership required to access) 

CE, CME and MOC 
AASLD offers many on-demand opportunities to earn CE, CME and or MOC through select online activities in LiverLearning®. Includes accredited activities for “Hepatology Self-Assessment Program” and “Fundamentals of Liver Disease.” Site is regularly updated to show the most current accredited activities (enduring material) that are offered.

Recorded Webinars  
AASLD webinars are online educational sessions that bring together a wide range of professionals to discuss the latest controversies and issues in the various sub-specialty fields of hepatology. Through these short, innovative sessions, participants can ask the experts questions about hot topics within their respective fields.  

Patient Education and Decision Support Tools

American Cancer Society (ACS) Resources 

Liver Cancer 
Information from the American Cancer Society about diagnosis and treatments.   

Blue Faery: The Adrienne Wilson Liver Cancer Association Resources
Blue Faery Website
Patient support and education resources including an online community and educational brochure. 

Patient Resource: Liver Cancer 
A guide for patients and families, developed by Patient Resource Publishing in partnership with Blue Faery, providing information about staging, treatment options, clinical trials, supportive care, caregiving, ongoing monitoring and care, and assistance. 

Cancer Support Community (CSC) Resources 

Frankly Speaking About Cancer: Liver Cancer 
From the Cancer Support Community's "Frankly Speaking About Cancer" series, information for patients about liver cancer. Downloadable booklet includes information on liver cancer, diagnosis, treatment options, managing treatment side effects, quality of life, support resources, and more. Download PDF

CSC Cancer Support Helpline® 
This toll-free Cancer Support Helpline is staffed by licensed mental health professionals 9:00 am- 9:00 pm ET for education, resources and support services. 1-888-793-9355 

Treatment Decision Support Tools 
The CSC’s Open to Options® is a decision-support counseling program designed to help prepare patients for appointments in which they will be making treatment decisions. The program is available in English or Spanish for people with any stage of cancer. 

CSC Affiliate Network 
Cancer Support Community Affiliates are located in many states across the U.S and have a wide range of support options for people diagnosed with cancer. 

This CSC resource allows patients/caregivers to create a personalized, online community to keep loved ones up-to-date and create a calendar of community support for the family. 

The Cancer Support Community's distress screening program, CancerSupportSource is the first comprehensive cancer distress screening program developed for community-based hospitals, physician practices, and advocacy organizations to integrate screening, referral and follow-up care, through a single, streamlined, program. 

Global Liver Institute Patient Resources

Liver Cancer Glossary  
From the Global Liver Institute, a comprehensive list of relevant terms and acronyms.

NCCN Patient Resources

NCCN Guidelines for Patients® Hepatobiliary Cancers: Liver, Bladder, and Bile Duct Cancers 
Part Four of the NCCN Guidelines explains treatment options for Hepatocellular Carcinoma (HCC). 

Other Decision Support Tools

Ottawa Personal Decision Guide 
From the Ottawa Hospital Research Institute, this template can be tailored to fit any health decision to be made. Includes a link to video segments illustrating each step of the shared decision-making process. 

Transplantation Resources

Evaluation for Liver Transplantation in Adults: 2013 Practice Guideline by the AASLD and the American Society of Transplantation  
This guideline provides specific recommendations, rationale, and supporting evidence for the evaluation for liver transplantation in adults. 

Referral for Liver Transplantation 
From Hepatitis C Online, this summary focuses on general guidance on adult liver transplantation and covers indications, contraindications, how to find information about transplant centers, and pre-transplantation evaluation.  

What are the optimal liver transplantation criteria for hepatocellular carcinoma? Mehta N, Yao FY. Clin Liver Dis. 2019;13:20-25. Discusses optimal liver transplantation criteria for patients with hepatocellular carcinoma (HCC).  

Outside Consultation for HCC Treatment

Liver Cancer Program, NCI Center for Cancer Research 
Includes information on how patients can get a second opinion through NCI. 

Clinical Trial and Research Resources

The Cancer Experience Registry 
This program of the Cancer Support Community is a unique online community that allows people facing cancer to share their experience, identify the issues that impact their lives, take surveys, access resources and learn from each other. It is free, confidential, and open to anyone who had been diagnosed with cancer or provides care to a patient with cancer.  

Hepatocellular Carcinoma Clinical Trials 
Trials search from NCI Center for Cancer Research.  

Other Articles & Resources
Faces, Facets, and Facts of the Unfamiliar Hepatocellular Carcinoma 

Fioravanti S, Walker M. Faces, facets, and facts of the unfamiliar hepatocellular carcinoma. Poster presented at: Growing Together. Transforming Care. Oncology Nursing Society 43rd Annual Congress. May 16 - 20, 2018, Washington, D.C. 

A Dream Team Leads the Fight Against Liver Disease. Levine D. In Health Matters. Spring/Summer 2018. White Plains Hospital: White Plains, NY. Profiles a multidisciplinary hepatobiliary program at White Plains Hospital.  

The Best of The Liver Meeting® 2019 - Liver and Biliary Cancer 
From the AASLD, The Best of The Liver Meeting® 2019 was created by the Scientific Program Committee for the benefit of AASLD members, attendees of the annual conference, and other clinicians involved in the treatment of liver diseases. The program highlights key presentations from the meeting and provides insights for patient care and ongoing research. 

Liver Cancer Resources from the Global Liver Institute 
A detailed landscape assessment of organizations working in liver cancer and related diseases and conditions.