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Liver Cancer

Liver cancer, which includes hepatocellular carcinoma (HCC), is the second leading cause of cancer-related death globally, responsible for more than 700,000 deaths worldwide each year.

Although this cancer type is less common in the United States, the American Cancer Society estimates that for 2021,42,230 new cases of primary liver cancer and intrahepatic bile duct cancer will be diagnosed and about 30,230 individuals will die of these cancers nationwide.

In the U.S., incidence rates of liver cancer in young adults have started to decline; however, the incidence of liver cancer in adults has more than tripled over the last 40 years. Nationally, death rates from liver cancer have increased by about one percent each year for women and have stabilized for men.

Effective prevention and treatment strategies for liver cancer remain an area of need. Active research in liver cancer is underway as several new therapies, including multikinase inhibitors and checkpoint inhibitor immunotherapy, have been approved to treat liver cancer, with more showing promise.

HCC Education and Protocols to Advance Treatment through Integrated Collaboration

The goal of this initiative is to provide the latest clinical information to increase clinicians’ knowledge and improve their competence confidence in providing the most accurate recommendations for treatment as members of the multidisciplinary HCC cancer treatment team.

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Multidisciplinary Hepatocellular Carcinoma Care

ACCC identified effective practices in multidisciplinary care hepatocellular carcinoma (HCC) and is providing peer-to-peer learning and resources for effective care coordination and communication.
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What They’re Saying

Wedd-Joel-100x100“HCC is a difficult disease to manage because of the multiple components of care required – no single provider can address all needs. A multidisciplinary approach puts patients at the center and results in better experience and outcomes.”
— Joel Wedd, MD, MPH, Director of the Liver Tumor Clinic, Emory Transplant Center, Emory Healthcare

Explore this program:

Effective Practices Publication
Results from cancer program case studies illustrate the complexities of the disease and care planning and reinforce the value of a multidisciplinary approach. Learn practical tips for improving communication and care coordination across the multidisciplinary cancer care team and with patients.

Liver Cancer Heatmap
Access ACCC’s Liver Cancer Heatmap to better understand the current incidence, mortality rates, and health disparities that exist across the United States.

HCC Resource Hub
Explore this curated resource bank to learn more about screening and treatment guidelines, training opportunities, patient education, and clinical trials for HCC.

From Oncology Issues

On-Demand Webinars

From the ACCCBuzz Blog


  1. American Cancer Society. Cancer Facts and Figures, 2021[]
  2. American Cancer Society. Key Statistics about Liver Cancer []
  3. Bucco D. Promising Liver Cancer Treatments on the Horizon. Cure Today. []
  4. Dobkowski, D. Patients with HCC Positively Respond to Opdivo with Yervoy When Nexavar Was Not an Option []