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Integration of MRD Testing: A Pathway for Patients with B-Cell Acute Lymphoblastic Leukemia

Testing for MRD can shape treatment choices and overall patient management to achieve better outcomes. Unfortunately, routine MRD testing is variable, and there are currently no standards for optimal MRD testing. To help address this deficiency, ACCC is conducting an educational project to create tools and recommend effective practices that multidisciplinary providers can use to successfully integrate MRD testing into their cancer care continuum—specifically for patients with B-cell acute lymphoblastic leukemia (ALL).

The project will provide information and guidance to members of multidisciplinary cancer care teams, including pathologists, oncologists, advanced practice providers, pharmacists, social workers, financial advocates, administrators, IT professionals, policy analysts, and other relevant specialists.

B-cell ALL was the first disease state with an FDA-approved treatment for MRD. This project will help lay the foundation for MRD testing in patients with B-cell ALL to create better-informed multidisciplinary cancer care teams. Ultimately, this work will showcase not only the importance of MRD testing, but also how it can be best integrated into the cancer care workflow.

Specifically, this project will:

  • Apply implementation science principles to promote guideline-concordant MRD testing for patients with B-cell ALL
  • Evaluate identified barriers and potential solutions to integrate MRD testing into ;community-based oncology practice
  • Develop an MRD testing model for the multidisciplinary cancer care team

To achieve these goals, ACCC will produce the following:

  • MRD Testing Integration Pathway: The integration pathway will be a valuable, non-clinical, online education ;tool for community-based cancer practices and programs seeking to integrate MRD testing into their treatment protocols for patients with B-cell ALL. The pathway will also offer basic education about the roles that various stakeholders play in MRD testing.
  • Resource Library: The resource library will house relevant content and address providers’ questions on the use of MRD testing for cancer.
  • Webinar Series: Three on-demand webinars will share with members of the cancer care team insights gleaned from the completion of the MRD Testing Integration Pathway.
  • Podcast: A podcast episode will educate cancer care team members about the implementation and purposes of MRD testing.
  • Publication: At the conclusion of the program, information, resources, and project findings will be shared in a print publication and posted on the ACCC website.

For more information about this project, please contact Limaya Atembina, MSW, Program Manager, ACCC Provider Education.

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