Multidisciplinary Advanced Cutaneous Squamous Cell Carcinoma Care

Cutaneous squamous cell carcinoma (cSCC), a cancer arising from malignant proliferation of epidermal keratinocytes,is the second most common skin cancer in the United States (after basal cell carcinoma), representing 20 - 50 percent of skin cancers.This cancer can develop on multiple skin surfaces, including the head, neck, trunk, extremities, oral mucosa, periungual skin, and anogenital areas. 

Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) together account for the vast majority of the skin cancers in the U.S. Of the two, BCC is far more common. (According to the American Cancer Society, of the estimated 3.3 million new cases of BCC and SCC diagnosed each year in the U.S., 8 out of 10 are BCC.)3  Thus, providers in the community setting are less likely to diagnose and treat patients with advanced cutaneous squamous cell carcinoma (cSCC) on a regular basis.

BCC rarely metastasizes; in contrast, 2 - 5 percent of cSCCs metastasize to regional lymph nodes or more distant sites.4 Although mortality for SCC is low, there can be significant morbidity associated with this disease, as well as a high cost of care, creating a significant risk to the patient’s quality of life.  

1. Que SK, Zwald F, Schmults C. Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging, 2018. J Am Acad Dermatol. 2018;78.2:237-47.
Lim JL, Asgari M. Epidemiology and risk factors for cutaneous squamous cell carcinoma. UpToDate. (Last updated Sept. 2018) Available at Accessed Dec. 6, 2018.
3. American Cancer Society. Key statistics for basal and squamous cell carcinoma. Available online at Accessed Dec. 6, 2018.
4. Aasi SZ, Hong A. Treatment and prognosis of low-risk cutaneous squamous cell carcinoma. (Last updated Nov. 2018) Accessed Dec. 6, 2018. Available at

Project Goal

For the Multidisciplinary Advanced Cutaneous Squamous Cell Carcinoma Care project, ACCC will provide examples of effective practices in diagnosing, testing, and treating this patient population to advance comprehensive care for people with cSCC.

Specifically, this project will provide:

  • expert insights provided by the project's experienced advisory committee in curating all project resources developed in support of education and awareness for cSCC.
  • a hub of resources for the multidisciplinary cancer care team.
  • a case studies publication that highlights effective practices in meeting the needs of this patient population.
  • live regional lecture series to facilitate peer-to-peer learning, expand local resources, and discuss the latest treatment techniques. 

Host a Regional Lecture!

The Regional Lecture Series are developed in conjunction with clinicians who care for patients with cSCC as well as high-risk non-melanoma skin cancers. If you are interested in hosting a regional lecture at your cancer program or practice, please email Hira Chowdhary, Project Manager, ACCC Provider Education.

Our Partner

AIM at Melanoma Foundation Logo 

Our Supporter

logo-Regeneron-200x80 Sanofi Logo
This project is sponsored by Regeneron and Sanofi.