Cutaneous squamous cell carcinoma (cSCC), a cancer arising from malignant proliferation of epidermal keratinocytes,1 is the second most common skin cancer in the United States (after basal cell carcinoma), representing 20 - 50 percent of skin cancers.1 This cancer can develop on multiple skin surfaces, including the head, neck, trunk, extremities, oral mucosa, periungual skin, and anogenital areas.2
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) together account for the vast majority of the skin cancers in the U.S. Of the two, BCC is far more common. (According to the American Cancer Society, of the estimated 3.3 million new cases of BCC and SCC diagnosed each year in the U.S., 8 out of 10 are BCC.)3 Thus, providers in the community setting are less likely to diagnose and treat patients with advanced cutaneous squamous cell carcinoma (cSCC) on a regular basis.
BCC rarely metastasizes; in contrast, 2 - 5 percent of cSCCs metastasize to regional lymph nodes or more distant sites.4 Although mortality for SCC is low, there can be significant morbidity associated with this disease, as well as a high cost of care, creating a significant risk to the patient’s quality of life.
This project will provide examples of effective practices in diagnosing, testing, and treating this patient population to advance comprehensive care for people with cSCC, including:
For questions or more information, please email Christie Mangir, MSOD, Manager, ACCC Provider Education.
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer in the U.S.; however, optimal identification and management of patients with high-risk features associated with recurrence or advanced cSCC can be complex and requires the expertise of multiple specialists.
This publication maps out effective practices in multidisciplinary cSCC management. Included are three care models from regionally diverse cancer programs located in areas of high cSCC prevalence.
ACCC thanks the following Cancer Program Members for their contributions to this publication:
Ellis Fischel Cancer Center
The George Washington University Cancer Center
The Knight Cancer Institute
Association of Community Cancer Centers Project Focuses on Multidisciplinary Cutaneous Squamous Cell Carcinoma Care
Dec 2, 2019
Que SK, Zwald F, Schmults C. Cutaneous squamous cell carcinoma: Incidence, risk factors, diagnosis, and staging, 2018. J Am Acad Dermatol. 2018;78.2:237-47.
Lim JL, Asgari M. Epidemiology and risk factors for cutaneous squamous cell carcinoma. UpToDate. (Last updated Sept. 2018) Available at UptoDate.com/contents/epidemiology-and-riskfactors-for-cutaneous-squamous-cell-carcinoma. Accessed Dec. 6, 2018.
American Cancer Society. Key statistics for basal and squamous cell carcinoma. Available online at www.cancer.org/cancer/basal-and-squamous-cell-skin-cancer/about/key-statistics.html. Accessed Dec. 6, 2018.
Aasi SZ, Hong A. Treatment and prognosis of low-risk cutaneous squamous cell carcinoma. (Last updated Nov. 2018) Accessed Dec. 6, 2018. Available at www.uptodate.com/contents/treatment-and-prognosis-of-low-risk-cutaneous-squamous-cell-carcinoma.