Antibody-drug conjugates (ADCs) are a rapidly advancing class of targeted cancer therapies that have gained significant attention in recent years. As of March 2025, the US Food and Drug Administration (FDA) has approved 13 ADCs for the treatment of various cancers, including hematologic malignancies and solid tumors, with many more in the clinical research pipeline.
To optimize patient outcomes, oncology providers and multidisciplinary care team members must stay up to date on emerging clinical trial data, patient selection criteria, toxicity management, and evolving treatment strategies. As understanding of ADCs continues to expand, their impact on the treatment of various cancer types is expected to grow.
This 2-part educational video series reviews the application of ADCs in gynecologic malignancies, possible adverse events, and management and mitigation strategies.
This 3-part educational video series provides a comprehensive overview of ADC treatment for NSCLC, its toxicity profile as well as the latest clinical advancements and applications for targeting TROP2 in NSCLC and potential in HER2 and HER3 NSCLC.
In this episode, CANCER BUZZ speaks with Manojkumar Bupathi, MD, President of Rocky Mountain Cancer Centers, about how ADCs are reshaping the care model toward earlier, structured collaboration between urology and medical oncology.
In this episode, CANCER BUZZ speaks with Terence Friedlander, MD, and Iva Petrovchich Colón, NP, both part of the team treating bladder cancer at the University of California, San Francisco (UCSF), about how their cancer program manages the toxicity profile of ADCs in order to prioritize patient outcomes and quality of life.
In this episode, CANCER BUZZ speaks with Cindy Y. Jiang, MD, assistant professor at MD Anderson Cancer Center, about how her institution conducted and implemented research to aid management of rashes and peripheral neuropathy associated with the ADC enfortumab vedotin combined with pembrolizumab.