In response to data that showed a significant decrease in both the volume of cancer screening tests and the number of cancer diagnoses, the James Cancer Diagnostic Center opened to provide patients with direct, expedited access to diagnostic testing. Open five days a week for same or next day in-person or virtual appointments, this advanced practice provider-led center provides a novel “front door” to the cancer hospital. To date more than 600 patients have been seen in this center, with 40% being referred onto a sub-specialty provider, offering a unique opportunity to extend diagnostic services from the inpatient to outpatient setting.