To improve patient care and reduce overall costs, the University of Arizona Cancer Center at Banner University Medical Center in Tucson—ACCC Innovator Award winner— transitioned to delivering select chemotherapies in its ambulatory clinics. Doing so took a significant coordinated effort. The task of assessing which chemotherapies could be safely administered in the outpatient setting took a multidisciplinary team a full year. The team then developed workflows for each chemotherapy to be administered in outpatient clinics and educated staff about the relevant chemotherapies’ potential side effects and toxicities. A year and a half after launching the effort, the University of Arizona Cancer Center transitioned to administering select chemotherapy its ambulatory clinics, reducing overnight hospital stays and lowering costs to patients and the health system.