Share

    


In This Section

Home / Learn / Cancer Types / Hematologic Malignancies

Hematologic Malignancies

Hematologic (blood) cancers, which impact the normal production and function of blood cells, often begin in bone marrow where stem cells develop into white blood cells, red blood cells, or platelets. These types of cancers occur when an uncontrolled growth of abnormal cells overtakes the development of normal blood cells, interfering with the regular functions of those cells. Hematologic cancers can be classified into three categories: leukemia, lymphoma, and multiple myeloma.

Developing quality improvement programs aimed at reducing health care disparities and improving the standard of care received by patients with hematologic cancers are key priorities in ACCC’s educational portfolio. Leverage our recent research and explore practical, actionable resources that you can implement in your cancer program today.

Acute Lymphocytic Leukemia (ALL)

Acute lymphocytic leukemia (ALL), also known as acute lymphoblastic leukemia, is a cancer of the blood and bone marrow.

Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia (AML) is the most diagnosed blood cancer in adults. ACCC has initiated the education program to explore and address current barriers in care coordination and alternative therapy options.

Chronic Lymphocytic Leukemia (CLL)

Chronic lymphocytic leukemia is a cancer of the B-lymphocytes that may be found in the bone marrow, blood, lymph nodes, spleen and sometimes other organs.

Follicular Lymphoma

Follicular lymphoma is a slow-growing yet incurable form of non-Hodgkin’s lymphoma, representing approximately 20-25% of NHL cases in the US.

Measurable Residual Disease (MRD) Testing

The MRD Implementation Roadmaps initiative will help multidisciplinary community cancer care teams better comprehend MRD testing by addressing barriers to incorporating the test into the treatment of ALL, CLL, and MM.

Multiple Myeloma (MM)

Multiple myeloma is the third most common hematologic cancer. However, compared to more frequently occurring cancers, multiple myeloma is relative rare and accounts for only 1.6 percent of diagnoses each year.

Myeloproliferative Neoplasms (MPNs)

Myeloproliferative neoplasms are blood cancers that carry a significant symptom burden and can develop aggressively. With no known cause and varying symptoms, myeloproliferative neoplasms can be difficult to diagnose and require meticulous treatment and follow-up care.

Reframing the Conversation: Effective Practices for Diffuse Large B-cell Lymphoma

Diffuse large B-cell lymphoma (DLBCL), is an aggressive disease affecting B-lymphocytes. There are many novel therapies and combination regimens currently being studied in clinical trials for the treatment of both newly diagnosed and relapsed/refractory DLBCL.

Relapsed/Refractory Mantle Cell Lymphoma (MCL)

Mantle cell lymphoma (MCL) is a rare and aggressive form of non-Hodgkin lymphoma (NHL). Access resources ACCC has developed to provide evidence-based guidelines on the management of MCL in the relapsed/refractory setting.

Returning to Practice in the Post-COVID-19 Era: Hematology Disease Education

Multiple myeloma is the third most common hematologic cancer. However, compared to more frequently occurring cancers, multiple myeloma is relative rare and accounts for only 1.6 percent of diagnoses each year.

Myelodysplastic Syndromes

Myelodysplastic syndromes (MDS) constitute a rare category of bone marrow disorders characterized by an accumulation of abnormal cells that can later progress to acute myeloid leukemia (AML).

Featured Resources

CLL_TreatmentGuideSheet_2024Treatment for Double-Exposed Chronic Lymphocytic Leukemia
Managing chronic lymphocytic leukemia (CLL) after double exposure to Bruton’s tyrosine kinase (BTK) and B-cell leukemia/lymphoma 2 (BCL2) inhibitors requires a tailored approach. This guide provides considerations and strategies to optimize outcomes for these patients.
Access Now.

Podcasts

  • Shared Decision-Making in CLL- [PODCAST] Ep. 184
    Apr 7, 2025

    Personalized therapeutic approaches for the treatment of chronic lymphocytic leukemia (CLL), guided by shared decision-making, can improve outcomes by aligning treatment with a patient’s unique clinical profile, preferences and goals. The Association of Cancer Care Centers (ACCC) is dedicated to providing up-to-date information on CLL management and treatment strategies. In this episode, CANCER BUZZ speaks with Christopher Nelson, ACNP, MBA, certified oncology nurse practitioner at Avera Medical Group Oncology & Hematology, to explore the importance of shared decision-making and patient communication in CLL. Additionally, CANCER BUZZ speaks with Meghan McGrath, MSN, RN, AGACNP, clinical trial nurse navigator at The Leukemia and Lymphoma Society (LLS), who discusses ways to incorporate clinical trials in the shared decision-making process and LLS services that are available to support patients and providers.

     

  • Establishing Goals of Treatment in Relapsed/Refractory Mantle Cell Lymphoma – [Video Podcast] Ep 51
    Oct 2, 2024
    In this episode, CANCER BUZZ speaks with Jeff Sharman, MD, medical director of hematology research, US Oncology, and director of research, Willamette Valley Cancer Institute, about the role of biomarker testing in guiding treatment decisions and how evidence-based management of treatment-related adverse events can serve this patient population.
  • Shared Decision Making in Relapsed/Refractory Mantle Cell Lymphoma – [Video Podcast] Ep 50
    Sep 24, 2024
    In this episode, CANCER BUZZ speaks with Nirav Shah, MD, MSHP, associate professor of medicine at Medical College of Wisconsin and Kirollos Hanna, PharmD, BCOP, PCOP, FACCC, assistant professor of pharmacy at Mayo Clinic and director of pharmacy at Minnesota Oncology, about shared decision making in the management of relapsed or refractory mantle cell lymphoma.
  • Adverse Event Management in Relapsed/Refractory Mantle Cell Lymphoma – [Video Podcast] Ep 48
    Aug 9, 2024

    In this episode, CANCER BUZZ speaks with Karen Fancher, PharmD, BCOP, clinical pharmacy specialist in oncology at University of Pittsburgh – Passavant Hospital, and Victoria Nachar, PharmD, BCOP, clinical pharmacist specialist in ambulatory hematology and adjunct clinical instructor at the University of Michigan, about strategies to address common adverse events experienced by patients with mantle cell lymphoma.  

  • How Do I Say It? Patient-Provider Communication in Diffuse Large B-Cell Lymphoma Care – [Video Podcast] Ep 47
    Jul 30, 2024

    In this episode, CANCER BUZZ speaks with Jean Louise Koff, MD, MSc, associate professor at Emory University School of Medicine in Atlanta, Georgia, about fostering trust, rapport, and collaboration in the patient-provider relationship.

  • Addressing Frequency of Care to Improve Quality of Life in Patients with Low-Risk MDS – [Video Podcast] Ep 46
    Jul 25, 2024

    In this episode, CANCER BUZZ speaks with David Sallman, MD, associate member in the Department of Malignant Hematology at Moffitt Cancer Center, and Karley Trautman, DNP, ANP-BC, AGACNP-BC, senior instructor of Medical Oncology at Highlands Ranch Cancer Center, to discuss best practices in the management of anemia in low-risk MDS patients.

  • A Multidisciplinary Approach to Anemia Management in High-Risk MDS and AML – [Video Podcast] Ep 42
    May 9, 2024

    In this episode, CANCER BUZZ speaks with Amy DeZern, MD, MHS, director, Bone Marrow Failure and MDS Program, Johns Hopkins University School of Medicine in Baltimore, Maryland; Donald Moore, PharmD, BCPS, BCOP, DPLA, FCCP, clinical oncology pharmacy manager, Atrium Health Levine Cancer in Charlotte, North Carolina; and David Sallman, MD, assistant member, Department of Malignant Hematology, Moffitt Cancer Center in Tampa, Florida. Their discussion elucidates an array of patient-centered approaches, touches on social determinants of health, and highlights collaborative measures to support care coordination in the management of anemia in patients with high-risk myelodysplastic syndrome and acute myeloid leukemia.

  • Navigating the Operational Challenges of Treatment with Bispecific Antibodies - [Podcast] Ep 148
    Mar 28, 2024

    Advancements in clinical data and research have shown the immunotherapeutic potential of bispecific antibodies as treatment for hematologic cancers and solid tumors. In this episode, CANCER BUZZ speaks with Aaron Cumpston, PharmD, pharmacy clinical specialist in hematologic malignancies and bone marrow transplant and Christine Barrett, PharmD, BCOP, medical oncology clinical pharmacy specialist at WVU Cancer Institute who discusses the challenges of care coordination and therapy and shares operational best practices for the delivery of bispecific antibodies in the community setting.

  • Disparities in Accessing Care for AML Patients: Challenges and Solutions – [Mini Podcast] Ep 145
    Mar 25, 2024

    In this episode, CANCER BUZZ speaks with Linda Hayward, patient financial advocate at the University of Maryland, Kaufman Cancer Center at Upper Chesapeake Health, about the challenges of treatment and strategies to address disparities in access and care for patients with acute myeloid leukemia.

  • Clarifying the Role of Maintenance Therapy - [Video Podcast] Ep 40
    Mar 14, 2024

    Maintenance therapy for patients with acute myeloid leukemia, particularly those who are ineligible for transplant, can be critical to treatment outcomes and quality of life for patients. In this episode, CANCER BUZZ speaks with Thomas LeBlanc, MD, hematologic oncologist, associate professor of Medicine, and associate professor in Population Health Sciences at Duke Cancer Institute, about the importance of keeping patients with acute myeloid leukemia in first remission as long as possible through maintenance therapy. 

  • Missed Care Conversations for Patients with DLBCL — [MINI PODCAST] EP 139
    Dec 21, 2023
    CANCER BUZZ spoke to Robin Atkins, RN, OCN, symptom triage nurse, Virginia Oncology Associates in Norfolk, Virginia. Listen as we discuss effective practices to support patients with diffuse large b-cell lymphoma throughout the care continuum.
  • AML Care Coordination in the Community Setting – [VIDEO PODCAST] Ep 39
    Oct 11, 2023

    Coordination of care for patients diagnosed with acute myeloid leukemia, particularly those who are ineligible for transplant, can impact access to specialist care, clinical trials, and cancer programs with advanced capabilities to treat patients with acute myeloid leukemia.

  • Strategies to Address Regional Barriers to Care in CLL  – [VIDEO PODCAST] Ep 38
    Aug 31, 2023

    In this episode, CANCER BUZZ speaks with Farrukh T. Awan, MD, MS, professor of Internal Medicine and director of Lymphoid Malignancies at the Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, about their approach to addressing regional barriers to improve care for patients with chronic lymphocytic leukemia.

  • Critical Conversation Strategies for Patients with AML  – [VIDEO PODCAST] Ep 37
    Jul 6, 2023

    Personalizing care goals to account for a patient’s values, preferences, or circumstances can make a significant difference in shared decision-making and treatment planning. In this episode, CANCER BUZZ speaks with Melissa Kah Poh Loh, MBBCh, BAO, assistant professor of Geriatric Hematology and Oncology at the University of Rochester Medical Center’s Wilmot Cancer Institute about strategies to optimize critical conversations with patients with acute myeloid leukemia.

  • Strategies to Addressing Disparities in Patients with AML – [VIDEO PODCAST] Ep 35
    Jun 22, 2023

    While there are many factors why patients with acute myeloid leukemia are ineligible for allogeneic stem cell transplant, such as age, financial hurdles, or other comorbidities, these factors are often compounded by social determinants of health, which can act as a significant barrier to consolidation therapy and long-term remission for these patients. In this episode, CANCER BUZZ speaks with Keri Maher, DO, Director of the Acute Leukemia Program, and assistant professor at Virginia Commonwealth University’s Massey Cancer Center about strategies to address these disparities and optimize care and treatment options for patients with acute myeloid leukemia who do not receive a transplant.

  • Alleviating the Psycho-social Burden of MPNs — [MINI PODCAST] EP 112
    May 16, 2023
    As myeloproliferative neoplasms (MPNs) carry a heavy symptom burden which can significantly impact a patient’s quality of life, hear how multidisciplinary care and psycho-social support can help alleviate this burden for patients.
  • Symptoms Scoring and Risk Stratification for Myelofibrosis — [MINI PODCAST] EP 109
    Apr 27, 2023
    Tune-in as Dr. Hobbs discusses symptom scoring, risk stratification, and effective practices in building a strong myelofibrosis program.
  • Utilizing Subcutaneous and IV Treatment for Improved Outcomes with Multiple Myeloma Patients — [MINI PODCAST] EP 108
    Apr 20, 2023
    Listen as Cindy Varga, MD, discusses the positives and negatives with subcutaneous versus intravenous drugs in treating patients with multiple myeloma.
  • In the Know: New Treatment Guidelines for Myeloproliferative Neoplasms – [VIDEO PODCAST] Ep 34
    Apr 6, 2023

    Learn how recent guideline and treatment options by the National Comprehensive Cancer Network (NCCN) can optimize care for patients with MPNs. 

  • The Impact of Integrated Care on Myeloproliferative Neoplasms (MPNs) – [VIDEO PODCAST] Ep 31
    Mar 9, 2023

    As myeloproliferative neoplasms (MPNs) carry a significant symptom burden and oftentimes can require lifelong care coordination and close monitoring, hear how a strong multidisciplinary approach can impact shared decision-making and patient engagement. 

  • Treatment Options for Patients with Multiple Myeloma Who Are Ineligible for Transplant — [PODCAST] EP 106
    Mar 3, 2023
    Over half of patients newly diagnosed with multiple myeloma are not eligible for transplant due to age or other major health problems. Listen as Dr. Yee provides treatment planning options available to patients who are ineligible for transplant.
  • The Urgency of MPN Treatment – Why Timing Matters – [VIDEO PODCAST] Ep 30
    Jan 26, 2023

    CANCER BUZZ speaks with Srdan Verstovsek, MD, PhD, about when to begin therapeutic care for myeloproliferative neoplasms (MPNs) and the urgency of treatment.

  • Improving Clinical Efficiency: EHR & MPN10 Integration – [VIDEO PODCAST] Ep 27
    Jan 4, 2023

    Hear why community practices need to monitor symptoms carefully and about a new tool that can help assess symptoms more accurately and help care teams form treatment plans.

  • [PODCAST] Ep 84: Increasing Clinical Trial Access for Blood Cancers
    Jun 7, 2022

    Clinical trials are the best instrument to advance treatment for blood cancers, but numerous challenges exist around trial identification, enrollment, and participation. We’ll hear perspectives from a community provider and patient advocacy organization on immediate—and forward-thinking—solutions to help this population better access clinical trials, including a tool from the Leukemia and Lymphoma Society to help patients identify cancer clinical trials that may be a fit.

  • [VIDEO PODCAST] Ep 08: Shared Decision-Making in Acute Myeloid Leukemia
    Oct 28, 2021

    Caring for patients with acute myeloid leukemia (AML) depends on many factors and can vary as much as the patients themselves.

  • [PODCAST] Ep 66: CLL, COVID-19, and Why Patient Registries Matter
    Aug 31, 2021

    In this episode, we'll hear how patients with blood cancer are joining the LLS National Patient Registry to increase scientific knowledge about COVID-19 vaccination and booster shot efficacy.

  • [VIDEO PODCAST] Ep 04: Chronic Lymphocytic Leukemia: Navigating Uncertainty
    Jul 22, 2021
    Three clinicians discuss their experiences with difficult conversations on the relative risks and benefits around treatment decisions in this rapidly evolving environment.
  • [PODCAST] Ep 61: CLL Patient Education in Transitional Times
    Jun 29, 2021

    As the COVID-19 pandemic recedes and restrictions loosens for most of the U.S., we'll discuss how patient education has become even more critical during this transition.

  • [VIDEO PODCAST] Ep 02: Myeloma Care Strategies & COVID-19
    Jun 3, 2021

    Three specialists in multiple myeloma care share their experiences that may help other providers and patients move smoothly through this time of transition while maintaining high quality care.

  • [PODCAST] Ep 57: COVID-19 Challenges: Managing Patients with CLL
    May 11, 2021
    A physician assistant shares the challenges related to COVID-19, the vaccine, and how his program is adapting to keep diagnosed patients with chronic lymphocytic leukemia (CLL) safe.

On-Demand Webinars

Resource Libraries

Digital toolkits offer resources and tools to support the multidisciplinary cancer team in providing quality care for patients.

 

Publications

Real-world case studies enable cancer programs to reflect on current practices to reduce variations in care and positively impact patient outcomes.

Multiple Myeloma Dispensing Models: Effective Practices to Improve Care Delivery and the Patient Experience
Real-world case studies from University of Illinois Hospital and Health Services System, Miami Cancer Institute at Baptist Health South Florida, and John Theurer Cancer Center at Hackensack University Medical Center, analyze and summarize their existing dispensing models and practices in caring for patients with multiple myeloma.

Multidisciplinary Chronic Lymphocytic Leukemia Care: Quality Improvement Case Studies
The Outer Banks Hospital, Billings Clinic Cancer Center, and the Ohio State University Comprehensive Cancer Center participated in quality improvement workshops in 2020.

Multidisciplinary Chronic Lymphocytic Leukemia Care: Models of Effective Care Delivery
To understand how patient-focused multidisciplinary care is effectively delivered across care settings, ACCC conducted site-visit focus groups at Self Regional Healthcare Cancer Center, The University of Kansas Cancer Center, and Sunrise Hospital and Medical Center.

Multidisciplinary Multiple Myeloma Care: Models of Effective Care Delivery
ACCC spoke with care team members at Yuma Regional Medical Center Cancer Center, John Theurer Cancer Center at Hackensack University Medical Center, and Moffitt Cancer Center to better understand how cancer centers are incorporating a multidisciplinary approach to diagnosing and managing patients with multiple myeloma.

From the ACCCBuzz Blog

From Oncology Issues